Complement C2 - CISMeF

Preferred Label : Complement C2;

NCIt synonyms : C3/C5 Convertase; Complement Component 2; EC 3.4.21.43; C2;

NCIt definition : Complement C2 (752 aa, 83 kDa) is encoded by the human C2 gene. This protein is involved in post-translational protein processing and complement activity.;

NCIt note : Complement C2 is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a is a serine proteainase that combines with complement factor C4b to form the C3 or C5 convertase. (UniProt);

NCI Metathesaurus CUI : CL1647978;

Details

Origin ID

C126958;

UMLS CUI

C4284454;

Automatic exact mappings (from CISMeF team)
- Complement component 2 [OMIM gene]
- complement C2 [ORDO Gene]
- complement C2 [HGNC gene]
- complement C3-C5 convertases [MeSH Descriptor]
Currated CISMeF NLP mapping
- Complement C2 [LOINC component]
- Complement component C2 (substance) [SNOMED CT concept]
- Complement factor C2 [MedDRA Preferred Term]
- complement C2 [MeSH concept]
- complement C2 [MeSH Descriptor]
- complement component c2, nos [SNOMED Notion]
OMIM relation
- Complement component 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- C2 Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
- Serine Protease [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_is_element_in_pathway
- Classical Complement Pathway [NCIt concept]
- Complement Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- C2 Deficiency [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Immunity [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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