Systemic Lupus Erythematosus Pathway

Preferred Label : Systemic Lupus Erythematosus Pathway;

NCIt synonyms : SLE Pathway;

NCIt related terms : Systemic lupus erythematosus;

Alternative definition : KEGG: Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particularly in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.;

KEGG ID : hsa05322;

Details

Origin ID

C91508;

UMLS CUI

C2984317;

Automatic exact mappings (from CISMeF team)
- DISSEMINATED LUPUS ERYTHEMATOSUS [WHO-ART Included Term]
- Lupus erythematosus systemic [MedDRA LLT]
- Systemic lupus erythematosus [OMIM Phenotype]
- Systemic lupus erythematosus [MedDRA Preferred Term]
- Systemic lupus erythematosus [HPO term]
- Systemic lupus erythematosus [ORDO Disease]
- Systemic lupus erythematosus [PASCAL descriptor]
- Systemic lupus erythematosus [ICD-11 Subcategory]
- Systemic lupus erythematosus [ICD-9 code]
- Systemic lupus erythematosus (disorder) [SNOMED CT concept]
- lupus [MedlinePlus Topic]
- lupus erythematosus, systemic [MeSH Descriptor]
- lupus erythematosus, systemic [MeSH concept]
- systemic lupus erythematosus [SNOMED Notion]
- systemic lupus erythematosus [DO Concept]
- systemic lupus erythematosus [Blood Transfusion thesaurus concept]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- 60 kDa SS-A/Ro Ribonucleoprotein [NCIt concept]
- Alpha-Actinin-1 [NCIt concept]
- Alpha-Actinin-4 [NCIt concept]
- CD40 Ligand [NCIt concept]
- Cathepsin G [NCIt concept]
- Complement C1q Subcomponent Subunit A [NCIt concept]
- Complement C1q Subcomponent Subunit B [NCIt concept]
- Complement C1q Subcomponent Subunit C [NCIt concept]
- Complement C1r Subcomponent [NCIt concept]
- Complement C1s Subcomponent [NCIt concept]
- Complement C2 [NCIt concept]
- Complement C4-A [NCIt concept]
- Complement C4-B [NCIt concept]
- Complement Component C6 [NCIt concept]
- Complement Component C8 Alpha Chain [NCIt concept]
- Complement Component C8 Beta Chain [NCIt concept]
- Complement Component C8 Gamma Chain [NCIt concept]
- Complement Component C9 [NCIt concept]
- Core Histone Macro-H2A.1 [NCIt concept]
- Core Histone Macro-H2A.2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM21 [NCIt concept]
- Glutamate Receptor Ionotropic, NMDA 2A [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Alpha Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DO Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- High Affinity Immunoglobulin Gamma Fc Receptor I [NCIt concept]
- Histone H2A Type 1 [NCIt concept]
- Histone H2A Type 1-A [NCIt concept]
- Histone H2A Type 1-B/E [NCIt concept]
- Histone H2A Type 1-C [NCIt concept]
- Histone H2A Type 1-D [NCIt concept]
- Histone H2A Type 1-H [NCIt concept]
- Histone H2A Type 1-J [NCIt concept]
- Histone H2A Type 2-A [NCIt concept]
- Histone H2A Type 2-B [NCIt concept]
- Histone H2A Type 2-C [NCIt concept]
- Histone H2A Type 3 [NCIt concept]
- Histone H2A-Bbd Type 1 [NCIt concept]
- Histone H2A-Bbd Type 2/3 [NCIt concept]
- Histone H2A.J [NCIt concept]
- Histone H2A.V [NCIt concept]
- Histone H2A.V Isoform 2 [NCIt concept]
- Histone H2A.Z [NCIt concept]
- Histone H2AX [NCIt concept]
- Histone H2B Type 1-A [NCIt concept]
- Histone H2B Type 1-B [NCIt concept]
- Histone H2B Type 1-C/E/F/G/I [NCIt concept]
- Histone H2B Type 1-D [NCIt concept]
- Histone H2B Type 1-H [NCIt concept]
- Histone H2B Type 1-J [NCIt concept]
- Histone H2B Type 1-K [NCIt concept]
- Histone H2B Type 1-L [NCIt concept]
- Histone H2B Type 1-M [NCIt concept]
- Histone H2B Type 1-N [NCIt concept]
- Histone H2B Type 1-O [NCIt concept]
- Histone H2B Type 2-E [NCIt concept]
- Histone H2B Type 2-F [NCIt concept]
- Histone H2B Type 3-B [NCIt concept]
- Histone H2B Type F-M [NCIt concept]
- Histone H2B Type W-T [NCIt concept]
- Histone H3.1 [NCIt concept]
- Histone H3.1t [NCIt concept]
- Histone H3.2 [NCIt concept]
- Histone H3.3 [NCIt concept]
- Histone H3.3C [NCIt concept]
- Histone H4 [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interleukin-10 [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B [NCIt concept]
- Lupus La Protein [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]
- T-Lymphocyte Activation Antigen CD80 [NCIt concept]
- T-Lymphocyte Activation Antigen CD86 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
pathway_has_gene_element
- ACTN1 wt Allele [NCIt concept]
- ACTN4 wt Allele [NCIt concept]
- C1QA wt Allele [NCIt concept]
- C1QB wt Allele [NCIt concept]
- C1QC wt Allele [NCIt concept]
- C1R wt Allele [NCIt concept]
- C1S wt Allele [NCIt concept]
- C2 wt Allele [NCIt concept]
- C4A wt Allele [NCIt concept]
- C4B wt Allele [NCIt concept]
- C6 wt Allele [NCIt concept]
- C8A wt Allele [NCIt concept]
- C8B wt Allele [NCIt concept]
- C8G wt Allele [NCIt concept]
- C9 wt Allele [NCIt concept]
- CD28 wt Allele [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- CD80 wt Allele [NCIt concept]
- CD86 wt Allele [NCIt concept]
- CTSG wt Allele [NCIt concept]
- FCGR1A wt Allele [NCIt concept]
- FCGR2A wt Allele [NCIt concept]
- FCGR3A wt Allele [NCIt concept]
- FCGR3B wt Allele [NCIt concept]
- GRIN2A wt Allele [NCIt concept]
- H2AB1 wt Allele [NCIt concept]
- H2AB2 wt Allele [NCIt concept]
- H2AB3 wt Allele [NCIt concept]
- H2AC1 wt Allele [NCIt concept]
- H2AC11 wt Allele [NCIt concept]
- H2AC12 wt Allele [NCIt concept]
- H2AC13 wt Allele [NCIt concept]
- H2AC14 wt Allele [NCIt concept]
- H2AC15 wt Allele [NCIt concept]
- H2AC16 wt Allele [NCIt concept]
- H2AC17 wt Allele [NCIt concept]
- H2AC18 wt Allele [NCIt concept]
- H2AC19 wt Allele [NCIt concept]
- H2AC20 wt Allele [NCIt concept]
- H2AC21 wt Allele [NCIt concept]
- H2AC25 wt Allele [NCIt concept]
- H2AC4 wt Allele [NCIt concept]
- H2AC6 wt Allele [NCIt concept]
- H2AC7 wt Allele [NCIt concept]
- H2AC8 wt Allele [NCIt concept]
- H2AJ wt Allele [NCIt concept]
- H2AX wt Allele [NCIt concept]
- H2AZ1 wt Allele [NCIt concept]
- H2AZ2 wt Allele [NCIt concept]
- H2BC1 wt Allele [NCIt concept]
- H2BC10 wt Allele [NCIt concept]
- H2BC11 wt Allele [NCIt concept]
- H2BC12 wt Allele [NCIt concept]
- H2BC13 wt Allele [NCIt concept]
- H2BC14 wt Allele [NCIt concept]
- H2BC15 wt Allele [NCIt concept]
- H2BC17 wt Allele [NCIt concept]
- H2BC18 wt Allele [NCIt concept]
- H2BC21 wt Allele [NCIt concept]
- H2BC26 wt Allele [NCIt concept]
- H2BC3 wt Allele [NCIt concept]
- H2BC4 wt Allele [NCIt concept]
- H2BC5 wt Allele [NCIt concept]
- H2BC6 wt Allele [NCIt concept]
- H2BC7 wt Allele [NCIt concept]
- H2BC8 wt Allele [NCIt concept]
- H2BC9 wt Allele [NCIt concept]
- H2BW1 wt Allele [NCIt concept]
- H2BW2 wt Allele [NCIt concept]
- H3-3A wt Allele [NCIt concept]
- H3-3B wt Allele [NCIt concept]
- H3-4 wt Allele [NCIt concept]
- H3-5 wt Allele [NCIt concept]
- H3C1 wt Allele [NCIt concept]
- H3C10 wt Allele [NCIt concept]
- H3C11 wt Allele [NCIt concept]
- H3C12 wt Allele [NCIt concept]
- H3C13 wt Allele [NCIt concept]
- H3C14 wt Allele [NCIt concept]
- H3C15 wt Allele [NCIt concept]
- H3C2 wt Allele [NCIt concept]
- H3C3 wt Allele [NCIt concept]
- H3C4 wt Allele [NCIt concept]
- H3C6 wt Allele [NCIt concept]
- H3C7 wt Allele [NCIt concept]
- H3C8 wt Allele [NCIt concept]
- H4C5 wt Allele [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLA-DOB wt Allele [NCIt concept]
- HLA-DQA1 wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- IL10 wt Allele [NCIt concept]
- MACROH2A1 wt Allele [NCIt concept]
- MACROH2A2 wt Allele [NCIt concept]
- RO60 wt Allele [NCIt concept]
- SNRPD3 wt Allele [NCIt concept]
- SSB wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TRIM21 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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