" /> Systemic Lupus Erythematosus Pathway - CISMeF





Preferred Label : Systemic Lupus Erythematosus Pathway;

NCIt synonyms : SLE Pathway;

NCIt related terms : Systemic lupus erythematosus;

Alternative definition : KEGG: Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particularly in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.;

KEGG ID : hsa05322;

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30/07/2025


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