Complement Activation

Preferred Label : Complement Activation;

NCIt definition : Any physiologic process in which a protease directs the cleavage of complement components C4, C2, or factor B which then form the C3 and C5 convertases for the classical and lectin pathways, respectively. This process is involved in direct lysis of target cells, immune adherence and phagocytosis of pathogens, and recruitment and activation of immunocompetent cells.;

Details

Origin ID

C21519;

UMLS CUI

C0009528;

Automatic exact mappings (from CISMeF team)
- obsolete complement activity [GO term]
Currated CISMeF NLP mapping
- complement activation [MeSH Descriptor]
- complement activation [MeSH concept]
False automatic mappings
- complement activation [GO term]
See also inter- (CISMeF)
- Complement activator (substance) [SNOMED CT concept]
- complement activator, nos [SNOMED Notion]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- complement activation [GO term]
- complement activation [MeSH concept]
- complement activation [MeSH Descriptor]
biological_process_has_initiator_chemical_or_drug
- Antigen [NCIt concept]
biological_process_involves_gene_product
- Acylation Stimulating Protein [NCIt concept]
- C3 Gene Product [NCIt concept]
- C3a Anaphylatoxin [NCIt concept]
- C4 Gene Product [NCIt concept]
- C4d [NCIt concept]
- C5 Gene Product [NCIt concept]
- C5a Anaphylatoxin [NCIt concept]
- C5a Anaphylatoxin Chemotactic Receptor 1 [NCIt concept]
- CUB and Sushi Domain-Containing Protein 1 [NCIt concept]
- Clusterin [NCIt concept]
- Complement C1q Subcomponent Subunit A [NCIt concept]
- Complement C1q Subcomponent Subunit B [NCIt concept]
- Complement C1q Subcomponent Subunit C [NCIt concept]
- Complement C1r Subcomponent [NCIt concept]
- Complement C1s Subcomponent [NCIt concept]
- Complement C2 [NCIt concept]
- Complement C3 [NCIt concept]
- Complement C3 Beta Chain [NCIt concept]
- Complement C3d [NCIt concept]
- Complement C4-A [NCIt concept]
- Complement C4-B [NCIt concept]
- Complement C5 [NCIt concept]
- Complement Component 1 Q Subcomponent-Binding Protein, Mitochondrial [NCIt concept]
- Complement Component C1 [NCIt concept]
- Complement Component C1q [NCIt concept]
- Complement Component C6 [NCIt concept]
- Complement Component C8 [NCIt concept]
- Complement Component C8 Alpha Chain [NCIt concept]
- Complement Component C8 Beta Chain [NCIt concept]
- Complement Component C8 Gamma Chain [NCIt concept]
- Complement Component C9 [NCIt concept]
- Complement Component Protein [NCIt concept]
- Complement Component-4 [NCIt concept]
- Complement Factor B [NCIt concept]
- Complement Factor D [NCIt concept]
- Complement Factor H [NCIt concept]
- Complement Factor H-Related Protein 1 [NCIt concept]
- Complement Factor H-Related Protein 5 [NCIt concept]
- Complement Factor I [NCIt concept]
- Complement Receptor Type 1 [NCIt concept]
- Complement Receptor Type 2 [NCIt concept]
- Ficolin-2 [NCIt concept]
- Ficolin-3 [NCIt concept]
- Immunoglobulin Kappa Constant [NCIt concept]
- Immunoglobulin Kappa Joining 1 [NCIt concept]
- Immunoglobulin Kappa Joining 2 [NCIt concept]
- Immunoglobulin Kappa Variable 1-39 [NCIt concept]
- Immunoglobulin Kappa Variable 1-5 [NCIt concept]
- Immunoglobulin Kappa Variable 2-30 [NCIt concept]
- Immunoglobulin Kappa Variable 4-1 [NCIt concept]
- Immunoglobulin Lambda Constant 1 [NCIt concept]
- Mannan-Binding Lectin Serine Protease 2 [NCIt concept]
- Plasma Protease C1 Inhibitor [NCIt concept]
- Properdin [NCIt concept]
biological_process_is_part_of_process
- Host Defense Mechanism [NCIt concept]
- Immunity [NCIt concept]
process_involves_gene
- C1QA Gene [NCIt concept]
- C1QA wt Allele [NCIt concept]
- C1QB Gene [NCIt concept]
- C1QB wt Allele [NCIt concept]
- C1QBP Gene [NCIt concept]
- C1QBP wt Allele [NCIt concept]
- C1QC Gene [NCIt concept]
- C1QC wt Allele [NCIt concept]
- C1R Gene [NCIt concept]
- C1R wt Allele [NCIt concept]
- C1S Gene [NCIt concept]
- C1S wt Allele [NCIt concept]
- C2 Gene [NCIt concept]
- C2 wt Allele [NCIt concept]
- C3 Gene [NCIt concept]
- C3 wt Allele [NCIt concept]
- C4A Gene [NCIt concept]
- C4A wt Allele [NCIt concept]
- C4B Gene [NCIt concept]
- C4B wt Allele [NCIt concept]
- C4B_2 Gene [NCIt concept]
- C4B_2 wt Allele [NCIt concept]
- C5 Gene [NCIt concept]
- C5 wt Allele [NCIt concept]
- C5AR1 Gene [NCIt concept]
- C5AR1 wt Allele [NCIt concept]
- C6 Gene [NCIt concept]
- C6 wt Allele [NCIt concept]
- C8A Gene [NCIt concept]
- C8A wt Allele [NCIt concept]
- C8B Gene [NCIt concept]
- C8B wt Allele [NCIt concept]
- C8G Gene [NCIt concept]
- C8G wt Allele [NCIt concept]
- C9 Gene [NCIt concept]
- C9 wt Allele [NCIt concept]
- CFB Gene [NCIt concept]
- CFB wt Allele [NCIt concept]
- CFD Gene [NCIt concept]
- CFD wt Allele [NCIt concept]
- CFH Gene [NCIt concept]
- CFH wt Allele [NCIt concept]
- CFHR1 Gene [NCIt concept]
- CFHR1 wt Allele [NCIt concept]
- CFHR5 Gene [NCIt concept]
- CFHR5 wt Allele [NCIt concept]
- CFI Gene [NCIt concept]
- CFI wt Allele [NCIt concept]
- CFP Gene [NCIt concept]
- CFP wt Allele [NCIt concept]
- CLU Gene [NCIt concept]
- CLU wt Allele [NCIt concept]
- CR1 Gene [NCIt concept]
- CR1 wt Allele [NCIt concept]
- CR2 Gene [NCIt concept]
- CR2 wt Allele [NCIt concept]
- CSMD1 Gene [NCIt concept]
- CSMD1 wt Allele [NCIt concept]
- Complement Component Gene [NCIt concept]
- FCN2 Gene [NCIt concept]
- FCN2 wt Allele [NCIt concept]
- FCN3 Gene [NCIt concept]
- FCN3 wt Allele [NCIt concept]
- IGKC Gene [NCIt concept]
- IGKC wt Allele [NCIt concept]
- IGKJ1 Gene [NCIt concept]
- IGKJ1 wt Allele [NCIt concept]
- IGKJ2 Gene [NCIt concept]
- IGKJ2 wt Allele [NCIt concept]
- IGKV1-39 Gene [NCIt concept]
- IGKV1-39 wt Allele [NCIt concept]
- IGKV1-5 Gene [NCIt concept]
- IGKV1-5 wt Allele [NCIt concept]
- IGKV2-30 Gene [NCIt concept]
- IGKV2-30 wt Allele [NCIt concept]
- IGKV4-1 Gene [NCIt concept]
- IGKV4-1 wt Allele [NCIt concept]
- IGLC1 Gene [NCIt concept]
- IGLC1 wt Allele [NCIt concept]
- MASP2 Gene [NCIt concept]
- MASP2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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