Complement Factor I

Preferred Label : Complement Factor I;

NCIt synonyms : Complement Component I; Complement Control Protein Factor I; EC 3.4.21.45; C3B/C4B Inactivator; CFI;

NCIt definition : Complement factor I (583 aa, 66 kDa) is encoded by the human CFI gene. This protein is involved in proteolytic inactivation of the alpha-chain of C3d and the alpha-chain of C4b, which leads to inhibition of the complement cascade.;

NCIt note : Complement factor I is synthesized as an inactive preproprotein that is cleaved to produce both heavy and light chains, which are linked by disulfide bonds and form the active heterodimeric glycoprotein. (EntrezGene);

Details

Origin ID

C198614;

OMIM relation
- Complement factor I [OMIM gene]
gene_encodes_gene_product
- CFI Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Scavenger Receptor Cysteine-Rich Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Negative Regulation of Complement Activation [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]

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