Complement Component C8

Preferred Label : Complement Component C8;

NCIt synonyms : Complement C8; C8; Complement Component 8;

NCIt definition : A heterotrimeric protein complex composed of complement component 8 (C8) chains alpha, beta and gamma. The alpha and gamma chains form a disulfide-linked dimer that is noncovalently associated with the beta chain. C8 inserts itself into target cell membranes following formation of the C5b-6-7 complex and then recruits 10-16 molecules of C9 to complete the formation of the membrane attack complex.;

NCI Metathesaurus CUI : CL1648593;

Details

Origin ID

C178619;

UMLS CUI

C5551434;

Automatic exact mappings (from CISMeF team)
- Complement C8 [LOINC component]
- complement C8 [MeSH Descriptor]
- complement C8 [MeSH concept]
Currated CISMeF NLP mapping
- Complement component C8 (substance) [SNOMED CT concept]
- complement component c8 [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
gene_encodes_gene_product
- Complement Component Gene [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
gene_product_is_physical_part_of
- Membrane Attack Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Activation of Membrane Attack Complex [NCIt concept]
- Complement Activation [NCIt concept]
has_gene_product_element
- Complement Component C8 Alpha Chain [NCIt concept]
- Complement Component C8 Beta Chain [NCIt concept]
- Complement Component C8 Gamma Chain [NCIt concept]
related_to_genetic_biomarker
- C8A Gene [NCIt concept]
- C8B Gene [NCIt concept]
- C8G Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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