Complement Factor B

Preferred Label : Complement Factor B;

NCIt synonyms : GBG; C3 Proaccelerator; C3/C5 Convertase; Factor B; Properdin Factor B; C3 Proactivator; Glycine-Rich Beta-Glycoprotein; EC 3.4.21.47; CFB; Glycine-Rich Beta Glycoprotein;

NCIt definition : Complement factor B (764 aa, 86 kDa) is encoded by the human CFB gene. This protein plays a role in C3/C5 convertase activity.;

NCIt note : Binding of complement factor B to complement C3 beta chain (C3b) forms C3 convertase. Binding of a second C3b molecule to the C3bBb complex (C3bBb3b complex) forms C5 convertase.;

NCI Metathesaurus CUI : CL1648581;

Details

Origin ID

C178649;

UMLS CUI

C5552910;

Automatic exact mappings (from CISMeF team)
- Complement factor B [LOINC component]
- Complement factor b [OMIM gene]
- Factor B (substance) [SNOMED CT concept]
- Sex hormone binding globulin [LOINC component]
- Sex steroid binding globulin (substance) [SNOMED CT concept]
- complement C3-C5 convertases [MeSH Descriptor]
- complement factor B [MeSH Descriptor]
- complement factor B [ORDO Gene]
- complement factor B [HGNC gene]
- complement factor B [MeSH concept]
OMIM relation
- Complement factor b [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
gene_encodes_gene_product
- CFB Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alternative Complement Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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