Complement factor b

Preferred Label : Complement factor b;

Obsolete resource : true;

Alternative titles and symbols : Cfb; Factor b; Fb; Properdin factor b; Bf; Factor b, properdin; C3 proactivator; C3 proaccelerator; Glycine-rich beta-glycoprotein; Gbgcomplement factor b deficiency; Cfbd;

Description : The CFB gene encodes complement factor B, which is part of the alternative complement pathway. Complement factor B is cleaved into a 30-kD N terminal 'Ba' fragment and a 57-kD C-terminal 'Bb' fragment by factor D (CFD; 134350) in the presence of C3b. The C-terminal half of the Bb fragment contains the essential active site residues characteristic of serine proteases, but has a molecular weight twice that of proteinases previously described, suggesting that it is a novel type of serine proteinase. The Bb fragment forms the C3bBb alternative pathway convertase (Christie and Gagnon, 1983). Complement factor B was originally known as a glycine-rich beta-glycoprotein (GBG).;

Details

Origin ID

138470;

UMLS CUI

C1824728;

Automatic exact mappings (from CISMeF team)
- 3'-(1-butylphosphoryl)adenosine [MeSH concept]
- 3'-(1-butylphosphoryl)adenosine [MeSH Supplementary Concept]
- Clofibrate [NCIt concept]
- FB Term Type [NCIt concept]
- Factor [NCIt concept]
- Followed by (attribute) [SNOMED CT concept]
- Mathematical Factor [NCIt concept]
- complement factor D [MeSH Descriptor]
- complement factor h [MeSH Descriptor]
- f factor [MeSH Descriptor]
- factor v [MeSH Descriptor]
- fibrinogen [MeSH Descriptor]
- obsolete alternative-complement-pathway C3/C5 convertase activity [GO term]
- properdin [MeSH Descriptor]
- prothrombin [MeSH Descriptor]
- thromboplastin [MeSH Descriptor]
Currated CISMeF NLP mapping
- Complement factor B [LOINC component]
- Factor B (substance) [SNOMED CT concept]
- complement factor B [MeSH Descriptor]
- complement factor B [MeSH concept]
- complement factor B [ORDO Gene]
- complement factor b, nos [SNOMED Notion]
False automatic mappings
- Bahamas [NCIt concept]
- Burkina Faso [NCIt concept]
NCIt concept(s)
- CFB Gene [NCIt concept]
- CFB wt Allele [NCIt concept]
- Complement Factor B [NCIt concept]
ORDO concept(s)
- complement factor B [ORDO Gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- CFB Gene [NCIt concept]
- complement factor B [HGNC gene]

Keyword's position in hierarchy(ies) :

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