Alternative titles and symbols : Cfb; Factor b; Fb; Properdin factor b; Bf; Factor b, properdin; C3 proactivator; C3 proaccelerator; Glycine-rich beta-glycoprotein; Gbgcomplement factor b deficiency; Cfbd;
Description : The CFB gene encodes complement factor B, which is part of the alternative complement
pathway. Complement factor B is cleaved into a 30-kD N terminal 'Ba' fragment and
a 57-kD C-terminal 'Bb' fragment by factor D (CFD; 134350) in the presence of C3b.
The C-terminal half of the Bb fragment contains the essential active site residues
characteristic of serine proteases, but has a molecular weight twice that of proteinases
previously described, suggesting that it is a novel type of serine proteinase. The
Bb fragment forms the C3bBb alternative pathway convertase (Christie and Gagnon, 1983).
Complement factor B was originally known as a glycine-rich beta-glycoprotein (GBG).;