C5a Anaphylatoxin

Preferred Label : C5a Anaphylatoxin;

NCIt synonyms : C5a; Anaphylatoxin C5a;

NCIt definition : C5a anaphylatoxin (74 aa, 8 kDa) is encoded by the human C5 gene. This protein is involved in the induction of smooth muscle contraction, the regulation of vascular permeability and the degranulation of both mast cells and basophils and the modulation of pathogen phagocytosis by neutrophils and monocytes.;

NCIt note : C5a anaphylatoxin is comprised of amino acids 678-751 of complement C5 and is produced through proteolysis of complement C5 into an alpha chain and a beta chain followed by further proteolysis of the complement C5 alpha chain. (UniProt);

Details

Origin ID

C20487;

UMLS CUI

C3890045;

OMIM relation
- Complement component 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
gene_encodes_gene_product
- C5 Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
- Complement Component Protein [NCIt concept]
gene_product_is_element_in_pathway
- Granulocyte Adhesion Pathway [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Complement Activation [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]

Keyword's position in hierarchy(ies) :

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