Preferred Label : Granulocyte Adhesion Pathway;
NCIt related terms : Adhesion and Diapedesis of Granulocytes;
Alternative definition : BIOCARTA: Cell adhesion is a fundamental feature of multicellular organisms including
their defense mechanisms. In the later case in mammals, leukocytes play central role.
They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions
with the endothelium are of special importance. During an inflammation or immune reaction,
specialized leukocytes (eosinophilic granulocytes) adhere to and pass through the
endothelium of the blood vessels and the underlying matrix. The reaction passes through
the following steps: 1. Rolling (the flow of cells is slowed down by first making
contacts to the endothelium via P-, E-, and L-selectins and their receptors); 2. Adhesion
(After activation of leukocyte integrins, firm contacts are established between them
and endothelium molecules of the Ig superfamily - LFA-1, Mac-1, VLA-4 etc.); 3. Flattening
of the cells and diapedesis (Adhering leukocytes crawl to an intercellular junction
of the endothelium and then transmigrate to or even through the intercellular matrix.
This is mediated by homophilic interactions of PECAM and CD31. (This definition may
be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_granulocytesPathway;
Origin ID : C39097;
UMLS CUI : C1512270;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
