P-Selectin - CISMeF

Preferred Label : P-Selectin;

NCIt synonyms : GMP-140; CD62; SELP; GMP140; Platelet Activation Dependent Granule-External Membrane Protein; CD62P Antigen; Platelet Alpha-Granule Membrane Protein; Granule Membrane Protein 140; LECAM3; PADGEM; Granulocyte Membrane Protein; Leukocyte-Endothelial Cell Adhesion Molecule 3; CD62 Antigen-Like Family Member P;

NCIt definition : P-selectin (830 aa, 91 kDa) is encoded by the human SELP gene. This protein plays a role in leukocyte adhesion to myeloid cells, endothelial cells or platelets.;

NCIt note : P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes. The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types. In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor. CD24 is a ligand for P-selectin. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin.;

Details

Origin ID

C17522;

UMLS CUI

C2742134;

Currated CISMeF NLP mapping
- P-Selectin [MeSH Descriptor]
- P-Selectin [MeSH concept]
- P-selectin [FMA entity]
OMIM relation
- Selectin p [OMIM gene]
See also inter- (CISMeF)
- Selectin p [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CD62P [LOINC component]
- SELP protein, human [MeSH concept]
- SELP protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- SELP Gene [NCIt concept]
gene_product_has_associated_anatomy
- Alpha Granule [NCIt concept]
- Endothelial Cell [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Selectin [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Sushi Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Granulocyte Adhesion Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Monocyte Phagocytosis and Adhesion Pathway [NCIt concept]
- Platelet Aggregation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
is_target
- Crizanlizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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