Preferred Label : Cell Adhesion Molecule Signaling Pathway;
NCIt synonyms : CAM Signaling Pathway;
NCIt related terms : Cell adhesion molecules (CAMs);
Alternative definition : KEGG: Cell adhesion molecules are (glyco)proteins expressed on the cell surface and
play a critical role in a wide array of biologic processes that include hemostasis,
the immune response, inflammation, embryogenesis, and development of neuronal tissue.
There are four main groups: the integrin family, the immunoglobulin superfamily, selectins,
and cadherins. Membrane proteins that mediate immune cell-cell interactions fall into
different categories, namely those involved in antigen recognition, costimulation
and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology
and highly coordinated brain functions such as memory and learning. During early development
of the nervous system, neurons elongate their axons towards their targets and establish
and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions
also underpin axon-axon contacts and link neurons with supporting schwann cells and
oligodendrocytes.;
KEGG ID : hsa04514;
Origin ID : C91461;
UMLS CUI : C2984273;
- Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element