Inducible T-Cell Costimulator

Preferred Label : Inducible T-Cell Costimulator;

NCIt synonyms : CD278; Antigen CD278; CD278 Antigen; Activation-Inducible Lymphocyte Immunomediatory Molecule; ICOS;

CISMeF synonym : CD278; ICOS;

NCIt definition : Inducible T-cell costimulator (199 aa, 23 kDa) is encoded by the human ICOS gene. This protein is involved in the regulation of T-cell antigen-mediated responses.;

Details

Origin ID

C94803;

UMLS CUI

C1570399;

OMIM relation
- Inducible t-cell costimulator [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- ICOS protein, human [MeSH Supplementary Concept]
- ICOS protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ICOS Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like V-Type Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Activation Co-Stimulatory Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Common Variable Immunodeficiency [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
- T-Cell Activation [NCIt concept]
is_target
- Acazicolcept [NCIt concept]
- Alomfilimab [NCIt concept]
- Anti-ICOS Agonist Monoclonal Antibody BMS-986226 [NCIt concept]
- Anti-ICOS Monoclonal Antibody MEDI-570 [NCIt concept]
- Feladilimab [NCIt concept]
- Izuralimab [NCIt concept]
- Vopratelimab [NCIt concept]

Keyword's position in hierarchy(ies) :

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