NCIt related terms : Anti-ICOS Agonist Monoclonal Antibody JTX-2011;
NCIt definition : An agonistic humanized monoclonal antibody that recognizes inducible T-cell co-stimulator
(ICOS; CD278), with potential antineoplastic activity. Upon administration, anti-ICOS
agonist monoclonal antibody JTX-2011 targets and binds to ICOS expressed on certain
T-cells. This stimulates ICOS-mediated signaling, induces proliferation of ICOS-positive
T-cells, enhances cytotoxic T-lymphocyte (CTL) survival and augments the CTL-mediated
immune response against tumor cells. ICOS, a T-cell specific, CD28-superfamily co-stimulatory
molecule and immune checkpoint protein, is normally expressed on certain activated
T-cells and plays a key role in the proliferation and activation of T-cells.;
UNII : QXN20J93AH;
CAS number : 2039148-04-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2039148-04-2
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Semantic type(s)