NCIt definition : An agonistic monoclonal antibody that recognizes inducible T-cell co-stimulator (ICOS;
CD278), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-ICOS agonist monoclonal antibody BMS-986226 targets and binds to ICOS expressed
on certain T-cells. This stimulates ICOS-mediated signaling, induces proliferation
of ICOS-positive T-cells, enhances cytotoxic T-lymphocyte (CTL) survival and augments
the CTL-mediated immune response against tumor cells. ICOS, a T-cell specific, CD28-superfamily
co-stimulatory molecule and immune checkpoint protein, is normally expressed on certain
activated T-cells and plays a key role in the proliferation and activation of T-cells.;
Semantic type(s)