Acazicolcept - CISMeF

Preferred Label : Acazicolcept;

NCIt synonyms : ICOSL vIgD-Fc; CD28/ICOS Antagonist ALPN-101;

NCIt definition : An Fc fusion protein comprised of a human inducible T-cell costimulator ligand (ICOSL) variant immunoglobulin domain (vIgD) that binds to both inducible T-cell costimulator (ICOS; CD278) and cluster of differentiation 28 (CD28), with potential immunomodulating activity. Upon administration, acazicolcept targets and binds to both CD28 and ICOS expressed on certain T-cells. This prevents the activation of CD28 and ICOS by its ligands, thereby blocking the two T-cell costimulatory pathways and the resulting T-cell activation. CD28 is involved in initiation of the pathogenic process in graft versus host disease (GVHD). Following initial activation, CD28 is often downregulated while ICOS is upregulated, possibly sustaining GVHD. Dual blockade of CD28 and ICOS may be superior to individual blockade of CD28 or ICOS alone.;

UNII : W507556HV0;

CAS number : 2270247-50-0;

Molecule name : ALPN 101; ALPN-101;

NCI Metathesaurus CUI : CL972908;

Details

Origin ID

C179069;

UMLS CUI

C5575168;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Inducible T-Cell Costimulator [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]

Keyword's position in hierarchy(ies) :

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