Preferred Label : Acazicolcept;
NCIt synonyms : ICOSL vIgD-Fc; CD28/ICOS Antagonist ALPN-101;
NCIt definition : An Fc fusion protein comprised of a human inducible T-cell costimulator ligand (ICOSL)
variant immunoglobulin domain (vIgD) that binds to both inducible T-cell costimulator
(ICOS; CD278) and cluster of differentiation 28 (CD28), with potential immunomodulating
activity. Upon administration, acazicolcept targets and binds to both CD28 and ICOS
expressed on certain T-cells. This prevents the activation of CD28 and ICOS by its
ligands, thereby blocking the two T-cell costimulatory pathways and the resulting
T-cell activation. CD28 is involved in initiation of the pathogenic process in graft
versus host disease (GVHD). Following initial activation, CD28 is often downregulated
while ICOS is upregulated, possibly sustaining GVHD. Dual blockade of CD28 and ICOS
may be superior to individual blockade of CD28 or ICOS alone.;
UNII : W507556HV0;
CAS number : 2270247-50-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2270247-50-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : ALPN 101; ALPN-101;
NCI Metathesaurus CUI : CL972908;
Origin ID : C179069;
UMLS CUI : C5575168;
Semantic type(s)
- concept_is_in_subset
- has_target
