" /> T-Cell-Specific Surface Glycoprotein CD28 - CISMeF





Preferred Label : T-Cell-Specific Surface Glycoprotein CD28;

NCIt synonyms : Tp44; T-Cell Antigen CD28; CD28; T90/44; CD28 Antigen; T-Cell-Specific Surface Glycoprotein; T-Cell Specific Surface Glycoprotein CD28; Antigen CD28;

NCIt definition : T-cell-specific surface glycoprotein CD28 (220 aa, 25 kDa) is encoded by the human CD28 gene. This protein is involved in the survival and activation of T-lymphocytes.;

NCIt note : CD28 encodes a highly glycosylated membrane protein with homology to the Ig superfamily. It also shares significant sequence identity with CTLA-4. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. CD28 is found on the membrane of resting T-cells. CD28 undergoes tyrosine phosphorylation after interacting with its ligand, B7. Phosphorylation in the cytoplasmic domain of CD28 allows the recruitment of signaling proteins such as PI3K, GRB2, and GADS via their SH2 domains. (OMIM);

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15/05/2024


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