Preferred Label : T-Cell Activation Pathway;
NCIt related terms : Role of Tob in T-cell activation;
Alternative definition : BIOCARTA: Regulation of T cell activation is a crucial component of balanced functioning
of the immune system. If the T cell response is too great and activation of self-responsive
cells or unstimulated cells is not suppressed, then autoimmune disorders or tissue
injury can result. Unstimulated T cells are maintained in a quiescent state and the
activity of self-reactive T cells is maintained in an anergic state in which IL-2
expression is repressed. IL-2 is a cytokine with a key role in the activation and
proliferation of T cells. The maintenance of T cells in the anergic or unstimulated
state may not involve just an absence of activation, but an active repression of IL-2
expression, T cell proliferation, and activation. TGF beta may play a role in suppressing
T cell activation. Tob is a member of a family of genes with anti-proliferative properties
that represses T cell activation. Tob expression is highest in unstimulated and anergic
T cells, and is reduced in activated T cells. Tob interacts with the TGF activated
transcription factors SMAD2 and SMAD4, increasing their binding to the IL-2 promoter,
and helping to repress IL-2 expression. This role of Tob suggests that interference
in Tob's function may lead to autoimmune disease. (This definition may be outdated
- see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_tob1Pathway;
Origin ID : C39256;
UMLS CUI : C1515122;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
