Interleukin-2 Receptor Subunit Alpha

Preferred Label : Interleukin-2 Receptor Subunit Alpha;

NCIt synonyms : IL2R; Low Affinity Interleukin 2 Receptor; IL2RA; IL-2R; IL-2 Receptor; Interleukin 2 Receptor, Alpha; Interleukin 2 Receptor; p55; Interleukin-2 Receptor Alpha; IL-2 Receptor Subunit Alpha; T-Cell Growth Factor Receptor; IL2-RA; IL-2R Subunit Alpha; Interleukin-2 Receptor Alpha Chain; TAC Antigen; IL-2-RA; IL2 Receptor;

NCIt related terms : CD25;

NCIt definition : Interleukin-2 receptor subunit alpha (272 aa, 31 kDa) is encoded by the human IL2RA gene. This protein plays a role in interleukin-2-dependent signaling.;

NCIt note : The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. (LocusLink);

Details

Origin ID

C17073;

UMLS CUI

C1700887;

Currated CISMeF NLP mapping
- Interleukin-2 receptor alpha subunit [MeSH concept]
- interleukin-2 receptor alpha subunit [MeSH Descriptor]
OMIM relation
- Interleukin 2 receptor, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL2RA protein, human [MeSH concept]
- IL2RA protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- Interleukin 2 receptor [LOINC component]
- Interleukin-2 receptor (substance) [SNOMED CT concept]
- interleukin-2 receptor site [SNOMED Notion]
- receptors, Interleukin-2 [MeSH concept]
- receptors, interleukin-2 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL2RA Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- LMB-2 Immunotoxin [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Sushi Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arf6 Trafficking Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Calcium Signaling in the CD4+ TCR Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL12/STAT4 Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2-Mediated Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- T-Cell Activation Pathway [NCIt concept]
- Th1/Th2 Differentiation Pathway [NCIt concept]
gene_product_is_physical_part_of
- Interleukin-2 Receptor [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-CD25 Monoclonal Antibody BA1106 [NCIt concept]
- Basiliximab [NCIt concept]
- Basiliximab-IR700 RM-1995 [NCIt concept]
- Camidanlumab Tesirine [NCIt concept]
- Daclizumab [NCIt concept]
- Indium In 111 Daclizumab [NCIt concept]
- Indium In 111-DOTA-Basiliximab [NCIt concept]
- LMB-2 Immunotoxin [NCIt concept]
- Pegylated CD25/CD122-selective Interleukin-2 Mutein STK-012 [NCIt concept]
- RFT5-dgA Immunotoxin IMTOX25 [NCIt concept]
- Vopikitug [NCIt concept]
- Yttrium Y 90 Basiliximab [NCIt concept]
- Yttrium Y 90 Daclizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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