Preferred Label : RFT5-dgA Immunotoxin IMTOX25;
NCIt synonyms : Anti-CD25 Immunotoxin IMTOX25; IgG-RFT5-dgA;
NCIt related terms : RFT5-dgA immunotoxin;
NCIt definition : A recombinant immunotoxin consisting of the anti-CD25 monoclonal antibody RFT5 fused
to the deglycosylated ricin A-chain (dgA) with potential antitumor activity. The monoclonal
antibody moiety of RFT5-dgA immunotoxin attaches to CD25 (the alpha chain of the IL-2
receptor complex) on the cell membrane; after internalization, the dgA moiety cleaves
the N-glycosidic bond between the ribose and adenine base at position 4324 in 28S
ribosomal RNA, resulting in ribosome inactivation, inhibition of protein synthesis,
and cell death. CD25 is expressed on activated normal T and B cells and macrophages
and is frequently upregulated in many hematologic malignancies.;
Alternative definition : NCI-GLOSS: A monoclonal antibody linked to a toxic substance. It is being studied
in the treatment of melanoma that has spread to distant parts of the body. IgG-RFT5-dgA
is made in the laboratory. It can find and kill certain white blood cells that prevent
the immune system from killing cancer cells.;
Molecule name : IMTOX25;
Codes from synonyms : CDR0000488414; CDR0000523318;
Origin ID : C61498;
UMLS CUI : C4764308;
Semantic type(s)
- concept_is_in_subset
- has_target
