Daclizumab - CISMeF

Preferred Label : Daclizumab;

NCIt synonyms : Anti-Tac; Humanized Anti-Tac Monoclonal Antibody; Monoclonal Antibody Anti-Tac; Anti-Tac Monoclonal Antibody; Anti-Tac Humanized Monoclonal Antibody;

NCIt related terms : Dacliximab;

NCIt definition : A recombinant monoclonal antibody interleukin-2 receptor antagonist. Daclizumab binds specifically to the alpha subunit of the human interleukin-2 (IL-2) receptor expressed on the surface of activated lymphocytes in vivo, thereby inhibiting IL-2 binding and IL-2-mediated lymphocyte activation, a critical cellular immune response pathway.;

Alternative definition : NCI-GLOSS: A monoclonal antibody that is being studied in the treatment of adult T-cell leukemia and in the treatment of cytopenia (low blood cell count).;

UNII : CUJ2MVI71Y;

CAS number : 152923-56-3;

Drug name : Zenapax;

NSC code : 725173;

Codes from synonyms : CDR0000045413; CDR0000044484;

Details

Origin ID

C1569;

UMLS CUI

C0663182;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Daclizumab [MeSH Descriptor]
- Daclizumab (substance) [SNOMED CT concept]
- Product containing daclizumab (medicinal product) [SNOMED CT concept]
- daclizumab [ATC Code]
- daclizumab [MeSH concept]
Validated automatic mappings to BTNT
- daclizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Interleukin-2 Receptor Subunit Alpha [NCIt concept]
is_component_of_chemotherapy_regimen
- Daclizumab/Interleukin-2 [NCIt concept]
- Daclizumab/Methylprednisolone [NCIt concept]
- Interleukin-2/Monoclonal Antibody Anti-Tac [NCIt concept]

Keyword's position in hierarchy(ies) :

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