Preferred Label : Indium In 111-DOTA-Basiliximab;
NCIt synonyms : 111In-DOTA-Basiliximab;
NCIt definition : A radioimmunoconjugate composed of basiliximab, a chimeric, mouse-human monoclonal
antibody directed against the alpha subunit of interleukin-2 receptor (IL-2R alpha,
CD25 or Tac antigen), and conjugated with the bifunctional, macrocyclic chelating
agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the radioisotope
indium In 111, with potential use as an imaging agent. Upon administration of indium
In 111-DOTA- basiliximab, the basiliximab moiety targets and binds to IL-2R alpha
expressed on the surface of activated T-lymphocytes. Upon binding and gamma scintigraphy,
IL-2R alpha-expressing T-cells can be visualized and the binding and biodistribution
of basiliximab can be assessed.;
NCI Metathesaurus CUI : CL1662098;
Origin ID : C179546;
UMLS CUI : C5555758;
Semantic type(s)
- concept_is_in_subset
- has_target
