IL2 Signaling Pathway

Preferred Label : IL2 Signaling Pathway;

NCIt related terms : IL 2 signaling pathway;

Alternative definition : BIOCARTA: Interleukin 2 (IL-2) is a potent cytokine that can lead to cellular activation and proliferation. IL-2 receptors are found on activated B-cells, LPS treated monocytes, and many T-cells. The receptor is formed from three chains, alpha (CD25), beta (CD122), and gamma (CD132). Primary signaling is through the JAK/Stat pathway and MAPKs. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il2Pathway;

Details

Origin ID

C39122;

UMLS CUI

C1512594;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Casein Kinase II Subunit Alpha [NCIt concept]
- Cytokine Receptor Common Subunit Gamma [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Interleukin-2 [NCIt concept]
- Interleukin-2 Receptor Subunit Alpha [NCIt concept]
- Interleukin-2 Receptor Subunit Beta [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
- Tyrosine-Protein Kinase Lck [NCIt concept]
- Tyrosine-Protein Kinase SYK [NCIt concept]
pathway_has_gene_element
- CSNK2A1 wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IL2 wt Allele [NCIt concept]
- IL2RA wt Allele [NCIt concept]
- IL2RB wt Allele [NCIt concept]
- IL2RG wt Allele [NCIt concept]
- JAK1 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- LCK wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]
- SYK wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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