Tyrosine-Protein Kinase JAK1

Preferred Label : Tyrosine-Protein Kinase JAK1;

NCIt synonyms : JAK1; EC 2.7.1.112; Janus Kinase-1; Janus Kinase 1; EC 2.7.10.2;

NCIt definition : Tyrosine-protein kinase JAK1 (1154 aa, 133 kDa) is encoded by the human JAK1 gene. This protein plays a role in both tyrosine phosphorylation and interferon-mediated signaling.;

NCIt note : Janus kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.;

Details

Origin ID

C28493;

UMLS CUI

C1527598;

Currated CISMeF NLP mapping
- Janus kinase 1 [COVID-19 Thesaurus concept]
- janus kinase 1 [MeSH Descriptor]
- janus kinase 1 [MeSH concept]
OMIM relation
- Janus kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- JAK1 protein, human [MeSH concept]
- JAK1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- JAK1 Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Janus Kinase Family [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- EGF Signaling Pathway [NCIt concept]
- IFN Alpha Signaling Pathway [NCIt concept]
- IFN Gamma Signaling Pathway [NCIt concept]
- IL10 Anti-inflammatory Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL22 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- IL7 Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Stat3 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Baricitinib [NCIt concept]
- Brepocitinib [NCIt concept]
- Cerdulatinib [NCIt concept]
- Golidocitinib [NCIt concept]
- Itacitinib [NCIt concept]
- Itacitinib Adipate [NCIt concept]
- Ivarmacitinib [NCIt concept]
- Ivarmacitinib Sulfate [NCIt concept]
- JAK1 Inhibitor INCB052793 [NCIt concept]
- Lorpucitinib [NCIt concept]
- Momelotinib [NCIt concept]
- Nezulcitinib [NCIt concept]
- Ruxolitinib [NCIt concept]
- Ruxolitinib Phosphate [NCIt concept]
- Ruxolitinib Phosphate Cream [NCIt concept]

Keyword's position in hierarchy(ies) :

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