Preferred Label : Golidocitinib;
NCIt synonyms : JAK1 Inhibitor AZD4205;
NCIt definition : An orally available inhibitor of Janus-associated kinase 1 (JAK1), with potential
antineoplastic activity. Upon oral administration, golidocitinib inhibits JAK-dependent
signaling and may lead to an inhibition of cellular proliferation in JAK1-overexpressing
tumor cells. The JAK-STAT (signal transducer and activator of transcription) signaling
pathway is a major mediator of cytokine activity and is often dysregulated in a variety
of tumor cell types. Additionally, JAK1 may be a primary driver of STAT3 phosphorylation
and signaling, which plays a role in neoplastic transformation, resistance to apoptosis,
tumor angiogenesis, metastasis, immune evasion, and treatment resistance.;
UNII : 3BY9Z3M34G;
CAS number : 2091134-68-6;
Molecule name : AZD 4205; AZD-4205;
NCI Metathesaurus CUI : CL935810;
Origin ID : C156774;
UMLS CUI : C5667174;
Semantic type(s)
- concept_is_in_subset
- has_target
