NCIt definition : A lung-selective inhibitor of the Janus associated-kinases (JAKs), with potential
immunomodulatory and anti-inflammatory activities. Upon administration via nebulized
inhalation, nezulcitinib inhibits the activity of the JAKs, thereby disrupting cytokine-induced
activation of JAK-STAT signaling pathways in the airways. This may inhibit the release
of pro-inflammatory cytokines and chemokines, reducing inflammatory responses and
preventing inflammation-induced damage. The Janus kinase family of non-receptor tyrosine
kinases, which includes tyrosine-protein kinase JAK1 (Janus kinase 1; JAK1), tyrosine-protein
kinase JAK2 (Janus kinase 2; JAK2), tyrosine-protein kinase JAK3 (Janus kinase 3;
JAK3) and non-receptor tyrosine-protein kinase TYK2 (tyrosine kinase 2), plays a key
role in cytokine signaling.;
UNII : CXA4I8AH6A;
CAS number : 2412496-23-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2412496-23-0
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