" /> Nezulcitinib - CISMeF





Preferred Label : Nezulcitinib;

NCIt synonyms : JAK1/JAK2/JAK3/TYK2 Inhibitor TD-0903;

NCIt definition : A lung-selective inhibitor of the Janus associated-kinases (JAKs), with potential immunomodulatory and anti-inflammatory activities. Upon administration via nebulized inhalation, nezulcitinib inhibits the activity of the JAKs, thereby disrupting cytokine-induced activation of JAK-STAT signaling pathways in the airways. This may inhibit the release of pro-inflammatory cytokines and chemokines, reducing inflammatory responses and preventing inflammation-induced damage. The Janus kinase family of non-receptor tyrosine kinases, which includes tyrosine-protein kinase JAK1 (Janus kinase 1; JAK1), tyrosine-protein kinase JAK2 (Janus kinase 2; JAK2), tyrosine-protein kinase JAK3 (Janus kinase 3; JAK3) and non-receptor tyrosine-protein kinase TYK2 (tyrosine kinase 2), plays a key role in cytokine signaling.;

UNII : CXA4I8AH6A;

CAS number : 2412496-23-0;

Molecule name : TD 0903; TD-0903;

NCI Metathesaurus CUI : CL1648383;

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24/05/2025


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