Tyrosine-Protein Kinase JAK2

Preferred Label : Tyrosine-Protein Kinase JAK2;

NCIt synonyms : Janus Kinase-2; JAK2; EC 2.7.1.112; JAK-2; Janus Kinase 2; EC 2.7.10.2;

NCIt definition : Tyrosine-protein kinase JAK2 (1132 aa, 131 kDa) is encoded by the human JAK2 gene. This protein is involved in immunity, tyrosine phosphorylation and signal transduction.;

NCIt note : Janus kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.;

Details

Origin ID

C28494;

UMLS CUI

C1527617;

Automatic exact mappings (from CISMeF team)
- AATK protein, human [MeSH Supplementary Concept]
- ABL-1 protein, C elegans [MeSH Supplementary Concept]
- Abl protein, Drosophila [MeSH Supplementary Concept]
- Agammaglobulinaemia Tyrosine Kinase [MeSH Descriptor]
- BTL protein, Drosophila [MeSH Supplementary Concept]
- Btk29A protein, drosophila [MeSH Supplementary Concept]
- CAM-1 protein, C elegans [MeSH Supplementary Concept]
- DDR1 protein, human [MeSH Supplementary Concept]
- DDR1 protein, rat [MeSH Supplementary Concept]
- EPHA3 protein, human [MeSH Supplementary Concept]
- Epha3 protein, mouse [MeSH Supplementary Concept]
- Epha3 protein, rat [MeSH Supplementary Concept]
- FES protein, human [MeSH Supplementary Concept]
- FGFR1 protein, human [MeSH Supplementary Concept]
- FGFR1 protein, strongylocentrotus purpuratus [MeSH Supplementary Concept]
- FGFR2 protein, human [MeSH Supplementary Concept]
- FGFR3 protein, human [MeSH Supplementary Concept]
- FGFR4 protein, human [MeSH Supplementary Concept]
- FLT3 protein, rat [MeSH Supplementary Concept]
- FRK protein, human [MeSH Supplementary Concept]
- FRK-1 protein, C elegans [MeSH Supplementary Concept]
- FYN protein, human [MeSH Supplementary Concept]
- Fak protein, Drosophila [MeSH Supplementary Concept]
- Fgfr1 protein, mouse [MeSH Supplementary Concept]
- Fgfr1 protein, rat [MeSH Supplementary Concept]
- Fgfr2 protein, mouse [MeSH Supplementary Concept]
- Fgfr2 protein, rat [MeSH Supplementary Concept]
- Fgfr2 protein, xenopus [MeSH Supplementary Concept]
- Fgfr3 protein, mouse [MeSH Supplementary Concept]
- Fgfr4 protein, mouse [MeSH Supplementary Concept]
- Fgfr4 protein, rat [MeSH Supplementary Concept]
- Flt1 protein, mouse [MeSH Supplementary Concept]
- Flt1 protein, rat [MeSH Supplementary Concept]
- Flt3 protein, mouse [MeSH Supplementary Concept]
- HCK protein, human [MeSH Supplementary Concept]
- HTK16 protein, hydra attenuata [MeSH Supplementary Concept]
- JAK1 protein, human [MeSH Supplementary Concept]
- JAK2 protein, human [MeSH Supplementary Concept]
- Jak1 protein, rat [MeSH Supplementary Concept]
- Jak2 protein, mouse [MeSH Supplementary Concept]
- Jak2 protein, rat [MeSH Supplementary Concept]
- Jak2a protein, zebrafish [MeSH Supplementary Concept]
- Jak3 protein, mouse [MeSH Supplementary Concept]
- Janus kinase 2 [ORDO Gene]
- Janus kinase 2 [OMIM gene]
- Janus kinase 2 [HGNC gene]
- Kos1 protein, mouse [MeSH Supplementary Concept]
- LIN-18 protein, C elegans [MeSH Supplementary Concept]
- MATK protein, human [MeSH Supplementary Concept]
- MERTK protein, human [MeSH Supplementary Concept]
- MET protein, human [MeSH Supplementary Concept]
- NOK protein, mouse [MeSH Supplementary Concept]
- Ntrk2 protein, mouse [MeSH Supplementary Concept]
- Old-2 protein, C elegans [MeSH Supplementary Concept]
- Otk protein, Drosophila [MeSH Supplementary Concept]
- PTK2 protein, human [MeSH Supplementary Concept]
- PTK6 protein, human [MeSH Supplementary Concept]
- PTK7 protein, xenopus [MeSH Supplementary Concept]
- Ptk2 protein, mouse [MeSH Supplementary Concept]
- Ptk2 protein, rat [MeSH Supplementary Concept]
- Ptk2b protein, mouse [MeSH Supplementary Concept]
- Ptk2b protein, rat [MeSH Supplementary Concept]
- Ptk7 protein, mouse [MeSH Supplementary Concept]
- RET protein, human [MeSH Supplementary Concept]
- RET-PTC oncoprotein, rat [MeSH Supplementary Concept]
- RYK protein, human [MeSH Supplementary Concept]
- Ret protein, Drosophila [MeSH Supplementary Concept]
- Ret-Ptc1 oncoprotein, mouse [MeSH Supplementary Concept]
- Ros1 protein, mouse [MeSH Supplementary Concept]
- Ros1 protein, rat [MeSH Supplementary Concept]
- SER receptor, schistosoma mansoni [MeSH Supplementary Concept]
- Scd-2 protein, C elegans [MeSH Supplementary Concept]
- SmRTK-1, schistosoma mansoni [MeSH Supplementary Concept]
- SmRTK-2, schistosoma mansoni [MeSH Supplementary Concept]
- Src42A protein, drosophila [MeSH Supplementary Concept]
- Src64B protein, drosophila [MeSH Supplementary Concept]
- TK4 protein, schistosoma mansoni [MeSH Supplementary Concept]
- TWF1 protein, human [MeSH Supplementary Concept]
- TWF2 protein, human [MeSH Supplementary Concept]
- TWF2 protein, mouse [MeSH Supplementary Concept]
- TYK2 protein, human [MeSH Supplementary Concept]
- Tnk2 protein, rat [MeSH Supplementary Concept]
- Tyk2 protein, mouse [MeSH Supplementary Concept]
- Tyk2 protein, rat [MeSH Supplementary Concept]
- Tyro3 protein, mouse [MeSH Supplementary Concept]
- Tyro3 protein, rat [MeSH Supplementary Concept]
- WZC protein, bacteria [MeSH Supplementary Concept]
- Wee1 protein, drosophila [MeSH Supplementary Concept]
- Wee1 protein, mouse [MeSH Supplementary Concept]
- YES1 protein, Xenopus [MeSH Supplementary Concept]
- Yes1 protein, mouse [MeSH Supplementary Concept]
- Yes1 protein, rat [MeSH Supplementary Concept]
- ZAP70 protein, human [MeSH Supplementary Concept]
- Zap70 protein, mouse [MeSH Supplementary Concept]
- aatk protein, mouse [MeSH Supplementary Concept]
- egfr protein, drosophila [MeSH Supplementary Concept]
- emt protein-tyrosine kinase [MeSH Supplementary Concept]
- epha4-b protein, Xenopus [MeSH Supplementary Concept]
- ephb4b protein, zebrafish [MeSH Supplementary Concept]
- fes protein, mouse [MeSH Supplementary Concept]
- fgfr2 protein, zebrafish [MeSH Supplementary Concept]
- fgfr3 protein, zebrafish [MeSH Supplementary Concept]
- fgfr4 protein, zebrafish [MeSH Supplementary Concept]
- fibroblast growth factor receptor-4, xenopus [MeSH Supplementary Concept]
- frk protein, mouse [MeSH Supplementary Concept]
- fyn protein, mouse [MeSH Supplementary Concept]
- fyn protein, rat [MeSH Supplementary Concept]
- fyn protein, xenopus [MeSH Supplementary Concept]
- fyna protein, zebrafish [MeSH Supplementary Concept]
- hck protein, mouse [MeSH Supplementary Concept]
- hck protein, rat [MeSH Supplementary Concept]
- hop protein, Drosophila [MeSH Supplementary Concept]
- htl protein, Drosophila [MeSH Supplementary Concept]
- jak1 protein, zebrafish [MeSH Supplementary Concept]
- ksy protein, xenopus [MeSH Supplementary Concept]
- let-23 protein, C elegans [MeSH Supplementary Concept]
- lyn protein-tyrosine kinase [MeSH Supplementary Concept]
- mertk protein, mouse [MeSH Supplementary Concept]
- mertk protein, rat [MeSH Supplementary Concept]
- pigeon protein, Drosophila [MeSH Supplementary Concept]
- proto-oncogene proteins c-fgr [MeSH Supplementary Concept]
- pvr protein, drosophila [MeSH Supplementary Concept]
- ret protein, mouse [MeSH Supplementary Concept]
- ret protein, rat [MeSH Supplementary Concept]
- ret-PTC fusion oncoproteins, human [MeSH Supplementary Concept]
- ryk protein, xenopus [MeSH Supplementary Concept]
- secErbB4-26-549 [MeSH Supplementary Concept]
- sev protein, drosophila [MeSH Supplementary Concept]
- tec protein, rat [MeSH Supplementary Concept]
- tek protein, zebrafish [MeSH Supplementary Concept]
- tie1 protein, zebrafish [MeSH Supplementary Concept]
- v-fps oncogene protein, fujinami sarcoma virus [MeSH Supplementary Concept]
- v-yes protein, avian sarcoma virus Y73 [MeSH Supplementary Concept]
- vab-1 protein, C elegans [MeSH Supplementary Concept]
- wzc protein, E coli [MeSH Supplementary Concept]
- yes1 protein, zebrafish [MeSH Supplementary Concept]
OMIM relation
- Janus kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- JAK2 protein, human [MeSH concept]
- JAK2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- JAK2 Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Janus Kinase Family [NCIt concept]
gene_product_has_gene_product_variant
- JAK2 NP_004963.1:p.E985K [NCIt concept]
- JAK2 NP_004963.1:p.G935R [NCIt concept]
- JAK2 NP_004963.1:p.G996R [NCIt concept]
- JAK2 NP_004963.1:p.I960V [NCIt concept]
- JAK2 NP_004963.1:p.M929I [NCIt concept]
- JAK2 NP_004963.1:p.R683G [NCIt concept]
- JAK2 NP_004963.1:p.R938L [NCIt concept]
- JAK2 NP_004963.1:p.T875N [NCIt concept]
- JAK2 NP_004963.1:p.V617F [NCIt concept]
- JAK2 NP_004963.1:p.V617X [NCIt concept]
- JAK2 NP_004963.1:p.Y931C [NCIt concept]
- JAK2 Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- Erythropoietin Neuroprotection Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- IFN Gamma Signaling Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL22 Signaling Pathway [NCIt concept]
- IL3 Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Interferon Signaling Modulation Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Hodgkin Lymphoma [NCIt concept]
- Polycythemia Vera [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Baricitinib [NCIt concept]
- Cerdulatinib [NCIt concept]
- Fedratinib [NCIt concept]
- Fedratinib Hydrochloride [NCIt concept]
- Flonoltinib Maleate [NCIt concept]
- Ilginatinib [NCIt concept]
- JAK2 Inhibitor AZD1480 [NCIt concept]
- JAK2 Inhibitor BMS-911543 [NCIt concept]
- JAK2 Inhibitor BS HH 002.SA [NCIt concept]
- JAK2 Inhibitor TQ05105 [NCIt concept]
- JAK2 Inhibitor XL019 [NCIt concept]
- Lorpucitinib [NCIt concept]
- Momelotinib [NCIt concept]
- Nezulcitinib [NCIt concept]
- Pacritinib [NCIt concept]
- Pacritinib Citrate [NCIt concept]
- Pacritinib Hydrochloride [NCIt concept]
- Ruxolitinib [NCIt concept]
- Ruxolitinib Phosphate [NCIt concept]
- Ruxolitinib Phosphate Cream [NCIt concept]
- Zotiraciclib Citrate [NCIt concept]

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