Non-Receptor Tyrosine-Protein Kinase TYK2

Preferred Label : Non-Receptor Tyrosine-Protein Kinase TYK2;

NCIt synonyms : EC 2.7.10.2;

NCIt definition : Non-receptor tyrosine-protein kinase TYK2 (1187 aa, 134 kDa) is encoded by the human TYK2 gene. This protein is involved in both tyrosine phosphorylation and signal transduction.;

Details

Origin ID

C101548;

UMLS CUI

C1448662;

Automatic exact mappings (from CISMeF team)
- TYK2 kinase [MeSH Descriptor]
OMIM relation
- Tyrosine kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TYK2 protein, human [MeSH concept]
- TYK2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- TYK2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- IFN Alpha Signaling Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL22 Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- Stat3 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Intercellular Communication Induction [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Induction [NCIt concept]
- Signal Transduction [NCIt concept]
- Signal Transduction Induction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Brepocitinib [NCIt concept]
- Lorpucitinib [NCIt concept]
- Nezulcitinib [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients