IL7 Signaling Pathway

Preferred Label : IL7 Signaling Pathway;

NCIt related terms : IL-7 Signal Transduction;

Alternative definition : BIOCARTA: IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T cells. Some humans with SCID (severe combined immunodeficiency disease) also have mutation of their IL-7 receptor gene leading to an absence of T cells and greatly impaired B cell production. The IL-7 receptor includes two polypeptides, a gamma chain and an alpha chain. The alpha-chain is unique to the IL-7 receptor while several other cytokines use the same gamma receptor chain as IL-7, including IL-2, IL-4, IL-9, IL-15 and IL-21. Binding of IL-7 to the alpha chain leads to dimerization of the alpha and gamma chains. JAK3 associated with the gamma chain tyrosine phosphorylates the alpha chain after dimerization. The importance of JAK3 in IL-7 signaling is supported by the similarity of the immune defects in JAK3 knockout mice and IL-7 knockout mice. The phosphorylated alpha chain serves as the site for recruiting other signaling molecules to the complex to be phosphorylated and activated, including STAT5, src kinases, PI3 kinase, Pyk2, and Bcl2 proteins. Some targets of IL-7 signaling contribute to cellular survival, including Bcl2 and Pyk2. Other targets contribute to cellular proliferation, including PI3 kinase, src family kinases (lck and fyn) and STAT5. The transcription factor STAT5 contributes to activation of multiple different downstream genes in B and T cells and may contribute to VDJ recombination through alteration of chromatin structure. The cell survival and cell proliferation signals induced by IL-7 combine to induce normal B and T cell development. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il7Pathway;

Details

Origin ID

C39128;

UMLS CUI

C1512599;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Apoptosis Regulator Bcl-2 [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Cytokine Receptor Common Subunit Gamma [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Integrin Alpha-IIb [NCIt concept]
- Interleukin-7 [NCIt concept]
- Interleukin-7 Receptor Subunit Alpha [NCIt concept]
- N-Myc-Interactor [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- STE20-Like Serine/Threonine-Protein Kinase [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
- Tyrosine-Protein Kinase Lck [NCIt concept]
pathway_has_gene_element
- BCL2 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- IL2RG wt Allele [NCIt concept]
- IL7 wt Allele [NCIt concept]
- IL7R wt Allele [NCIt concept]
- ITGA2B wt Allele [NCIt concept]
- JAK1 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- LCK wt Allele [NCIt concept]
- NMI wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PTK2B wt Allele [NCIt concept]
- SLK wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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