LCK wt Allele - CISMeF

Preferred Label : LCK wt Allele;

NCIt synonyms : Lymphocyte-Specific Protein Tyrosine Kinase Gene; LCK Proto-Oncogene, Src Family Tyrosine Kinase wt Allele; p56lck; LSK; YT16; pp58lck; IMD22;

NCIt definition : Human LCK wild-type allele is located in the vicinity of 1p34.3 and is approximately 35 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase LCK protein, plays a role in T-cell antigen receptor-linked signal transduction pathways. The LCK gene is associated with acute lymphoblastic leukemia and severe combined immunodeficiency.;

NCIt note : The LCK gene is expressed at all stages of thymocyte development. This gene is also involved in natural killer cell-mediated cytotoxicity.;

GenBank Accession Number : NM_005356;

Details

Origin ID

C51119;

UMLS CUI

C1708618;

OMIM relation
- Lck protooncogene, src family tyrosine kinase [OMIM gene]
See also inter- (CISMeF)
- Immunodeficiency 22 [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 32409019-32420854 [NCIt concept]
gene_in_chromosomal_location
- 1p35-p34.3 [NCIt concept]
gene_is_element_in_pathway
- Atypical NF-kappaB Signaling Pathway [NCIt concept]
- CSK Protein Kinase Activation Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL7 Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Activation Co-Stimulatory Signaling Pathway [NCIt concept]
- T-Cell Apoptosis Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- TCR Activation Pathway [NCIt concept]
gene_plays_role_in_process
- B-Cell Activation [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Activation [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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