Preferred Label : Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform;
NCIt synonyms : Phosphoinositide-3-Kinase Gamma Catalytic Subunit; PIK3CG; PtdIns-3-Kinase p110; 1-Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3 Kinase Gamma, p110 Gamma; PI3-Kinase; PTDINS-3-Kinase; Phosphatidylinositol 3-Kinase Catalytic 110-kD Gamma; PI3KGamma; PI3K; Phosphatidylinositol 3-Kinase, Catalytic, Gamma Polypeptide; p110-Gamma; PI3-Kinase p110 Subunit Gamma; EC 2.7.1.153; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Gamma Isoform; PIK3-Gamma; Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Gamma; Phosphatidylinositol 3-Kinase, Catalytic, Gamma; EC 2.7.11.1; PI3-Kinase Subunit Gamma; Serine/Threonine Protein Kinase PIK3CG; Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 kDa Catalytic Subunit Gamma; PtdIns-3-Kinase Subunit Gamma; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform; p110gamma; PtdIns-3-Kinase Subunit p110-Gamma; p120-PI3K; PI3K-Gamma;
NCIt definition : Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (1102
aa, 126 kDa) is encoded by the human PIK3CG gene. This protein plays a role in phosphoinositide
phosphorylation.;
NCIt note : Protein_Plays_Role_In_Biological_Process: Cytotoxicity; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform phosphorylates
phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important
modulator of extracellular signals, including those elicited by E-cadherin-mediated
cell-cell adhesion, which plays an important role in maintenance of the structural
and functional integrity of epithelia. In addition to its role in promoting assembly
of adherens junctions, the protein is thought to play a pivotal role in the regulation
of cytotoxicity in NK cells. (from LocusLink);
Origin ID : C30171;
UMLS CUI : C2713509;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_is_physical_part_of
- gene_product_plays_role_in_biological_process
- is_target
