Cytokine Receptor Common Subunit Gamma

Preferred Label : Cytokine Receptor Common Subunit Gamma;

NCIt synonyms : Interleukin 2 Receptor, Gamma; Common Cytokine Receptor Gamma Chain; IL2RG; Interleukin 2 Receptor, Gamma Chain; CD132; Common Gamma Chain; p64; Interleukin-2 Receptor Subunit Gamma; Interleukin-2 Receptor Gamma; IL-2RG; Interleukin 2 Receptor Gamma; CD132 Antigen; IL-2 Receptor Subunit Gamma; IL-2R Subunit Gamma; GammaC;

NCIt definition : Cytokine receptor common subunit gamma (369 aa, 42 kDa) is encoded by the human IL2RG gene. This protein plays a role in both immune responses and interleukin signaling.;

NCIt note : Cytokine receptor common subunit gamma is a component of many interleukin receptors (including IL2, IL4, IL7, IL9, IL15 and IL21).;

Details

Origin ID

C26266;

UMLS CUI

C1568975;

OMIM relation
- Interleukin 2 receptor, gamma [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL2RG protein, human [MeSH concept]
- IL2RG protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL2RG Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- IL7 Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
gene_product_is_physical_part_of
- Interleukin-15 Receptor [NCIt concept]
- Interleukin-2 Receptor [NCIt concept]
gene_product_malfunction_associated_with_disease
- Severe Combined Immunodeficiency [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-interleukin-2 Receptor Subunit Gamma Monoclonal Antibody REGN7257 [NCIt concept]
- IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1 [NCIt concept]
- Interleukin-2/Interleukin-15 Receptor Agonist NL-201 [NCIt concept]
- TransCon IL-2 Beta/Gamma [NCIt concept]

Keyword's position in hierarchy(ies) :

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