Preferred Label : IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1;
NCIt definition : A pegylated peptide antagonist that binds to the common gamma chain (gc; IL2RG; CD132)
of the signaling receptor for the pro-inflammatory cytokines interleukin (IL)-2, IL-9,
and IL-15, with potential immunomodulating and antineoplastic activities. Upon administration,
IL-2/9/15 gc receptor inhibitor BNZ-1 specifically targets and binds to the IL binding
site on the gc receptor and blocks IL-2, IL-9 and IL-15 binding, thereby inhibiting
IL-2-, IL-9-, and IL-15-mediated signaling and downstream pathways. This may inhibit
proliferation of tumor cells that are dependent on IL-2/9/15 signaling for their growth.
IL-2/9/15 are upregulated in certain tumor cell types and play a key role in tumor
progression and survival.;
Molecule name : BNZ-1; BNZ132-1-40;
NCI Metathesaurus CUI : CL544668;
Origin ID : C146636;
UMLS CUI : C4687395;
Semantic type(s)
- concept_is_in_subset
- has_target
