Anti-interleukin-2 Receptor Subunit Gamma Monoclonal Antibody REGN7257

Preferred Label : Anti-interleukin-2 Receptor Subunit Gamma Monoclonal Antibody REGN7257;

NCIt synonyms : Anti-IL2RG Monoclonal Antibody REGN7257; Anti-cytokine Receptor Common Subunit Gamma Monoclonal Antibody REGN7257; Anti-gamma Chain Receptor Monoclonal Antibody REGN7257;

NCIt definition : A monoclonal antibody targeted against interleukin-2 (IL-2) receptor subunit gamma (IL2RG; CD132; cytokine receptor common subunit gamma; gamma chain; gc), with potential immunomodulatory activity. Upon administration, anti-IL2RG monoclonal antibody REGN7257 targets and binds to the gamma subunit of the human IL-2 receptor (IL-2R) expressed on the surface of activated T-lymphocytes, thereby inhibiting IL-2 binding and IL-2-mediated T-cell activation. This may block T-cell-mediated immune responses. IL2RG plays a role in both immune responses and interleukin signaling.;

Molecule name : REGN-7257; REGN 7257;

NCI Metathesaurus CUI : CL1407963;

Details

Origin ID

C174059;

UMLS CUI

C5418064;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Cytokine Receptor Common Subunit Gamma [NCIt concept]

Keyword's position in hierarchy(ies) :

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