Preferred Label : Interleukin-2/Interleukin-15 Receptor Agonist NL-201;
NCIt synonyms : IL-2/IL-15 Receptor Agonist NL-201;
NCIt definition : An interleukin-2 (IL-2) and interleukin-15 (IL-15) receptor agonist with high binding
affinity for the common heterodimeric receptor IL-2Rbeta-gamma, which is composed
of the IL-2 receptor subunit beta (IL-2Rbeta; CD122) and IL-2 receptor subunit gamma
(IL-2Rgamma; common gamma; CD132), and no binding affinity for the IL-2 receptor subunit
alpha (IL-2Ralpha; CD25), with potential immunoregulatory and antineoplastic activities.
Upon administration, IL-2/IL-15 receptor agonist NL-201 targets and binds to IL-2Rbeta-gamma
on natural killer (NK) and T-cells and activates IL-2Rbeta-gamma-mediated signaling.
This induces the selective proliferation of CD8 T-cells and NK cells, enhances tumor
cell killing and decreases tumor cell proliferation. NL-201 does not bind to IL-2Ralpha,
thereby circumventing both the activation of immunosuppressive regulatory T-cells
(Tregs) and the exacerbation of vascular leak syndrome associated with recombinant
human IL-2. IL-2 and IL-15 receptors are cytokine receptors that play key roles in
the immune response.;
Molecule name : NL-201; NL 201;
NCI Metathesaurus CUI : CL1642882;
Origin ID : C176866;
UMLS CUI : C5447480;
Semantic type(s)
- concept_is_in_subset
- has_target
