Interleukin-2 Receptor Subunit Beta

Preferred Label : Interleukin-2 Receptor Subunit Beta;

NCIt synonyms : IL2RB; CD122; Interleukin 2 Receptor Beta; p75; Interleukin-2 Receptor Beta Chain; P70-75; CD122 Antigen; Intermediate Affinity Interleukin 2 Receptor Beta Subunit; IL-2 Receptor Subunit Beta; IL2 Receptor Beta; Medium Affinity Interleukin 2 Receptor Subunit Beta; Intermediate Affinity Interleukin 2 Receptor Subunit Beta; High Affinity IL-2 Receptor Subunit Beta; IL-2R Subunit Beta; Medium Affinity Interleukin 2 Receptor Beta Subunit; IL-2RB; High Affinity IL-2 Receptor Beta Subunit; Interleukin-2 Receptor Beta;

NCIt definition : Interleukin-2 receptor subunit beta (551 aa, 61 kDa) is encoded by the human IL2RB gene. This protein is involved in signal transduction-mediated by and receptor mediated endocytosis of interleukin-2.;

NCIt note : This protein is the beta subunit of the interleukin 2 receptor and is a type I membrane protein. It is involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. It plays a role in the T cell mediated immune response and is a member of the cytokine receptor family.;

Details

Origin ID

C26267;

UMLS CUI

C1259013;

OMIM relation
- Interleukin 2 receptor, beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL2RB protein, human [MeSH concept]
- IL2RB protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL2RB Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_product_is_physical_part_of
- Interleukin-15 Receptor [NCIt concept]
- Interleukin-2 Receptor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Mediated Immunity [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1 [NCIt concept]
- Anti-CD25-IL-2 Monoclonal Antibody AU-007 [NCIt concept]
- Bempegaldesleukin [NCIt concept]
- CD122-selective IL-2/Anti-CD25 Antibody-like Fusion Protein ANV419 [NCIt concept]
- IL-2 Superkine-Recombinant Human Albumin Fusion Protein MDNA11 [NCIt concept]
- Interleukin-2/Interleukin-15 Receptor Agonist NL-201 [NCIt concept]
- Monoclonal Antibody Mik-Beta-1 [NCIt concept]
- Pegylated CD25/CD122-selective Interleukin-2 Mutein STK-012 [NCIt concept]
- Ribocytokine IL-2 BNT153 [NCIt concept]
- TransCon IL-2 Beta/Gamma [NCIt concept]

Keyword's position in hierarchy(ies) :

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