" /> Ribocytokine IL-2 BNT153 - CISMeF





Preferred Label : Ribocytokine IL-2 BNT153;

NCIt synonyms : Human Interleukin-2 mRNA-encoded BNT153; BNT-153;

NCIt definition : A formulation consisting of lipid nanoparticles (LNPs) encapsulating nucleoside-modified messenger RNA (mRNA) encoding the endogenous cytokine interleukin-2 (IL-2), with potential immunostimulating activity. Upon administration, ribocytokine IL-2 BNT153 is taken up by cells and the expressed IL-2 targets and binds to the IL-2 receptor beta subunit (IL2Rb; IL2Rbeta; CD122). The binding of IL-2 to IL2Rb activates IL2Rb-mediated signaling, which activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). The specific induction of T-cell-mediated cytotoxic immune responses against tumor cells causes tumor cell destruction. IL2Rb plays a key role in the proliferation and activation of effector T-cells.;

Molecule name : BNT153; BNT 153;

NCI Metathesaurus CUI : CL1662151;

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16/05/2024


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