NCIt synonyms : Human Interleukin-2 mRNA-encoded BNT153; BNT-153;
NCIt related terms : BNT-153 MRNA;
NCIt definition : A formulation consisting of lipid nanoparticles (LNPs) encapsulating nucleoside-modified
messenger RNA (mRNA) encoding the endogenous cytokine interleukin-2 (IL-2), with potential
immunostimulating activity. Upon administration, ribocytokine IL-2 BNT153 is taken
up by cells and the expressed IL-2 targets and binds to the IL-2 receptor beta subunit
(IL2Rb; IL2Rbeta; CD122). The binding of IL-2 to IL2Rb activates IL2Rb-mediated signaling,
which activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and
induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg)
and transforming growth factor-beta (TGFb). The specific induction of T-cell-mediated
cytotoxic immune responses against tumor cells causes tumor cell destruction. IL2Rb
plays a key role in the proliferation and activation of effector T-cells.;