IL4 Signaling Pathway

Preferred Label : IL4 Signaling Pathway;

NCIt related terms : IL 4 signaling pathway;

Alternative definition : BIOCARTA: Interleukin 4 (IL-4) is a cytokine that can lead to development of Th2 cells. The 140 kD IL-4 Receptor (CD124) is found on many cell types, even those of non-hematopoietic origin. The receptor is formed from two chains: IL-4R-alpha and the IL-2R gamma chain (CD132). Primary signaling is through the JAK/Stat6 pathway and MAPKs. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il4Pathway;

Details

Origin ID

C39125;

UMLS CUI

C1512596;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Cytokine Receptor Common Subunit Gamma [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Insulin Receptor Substrate 1 [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-4 Receptor Subunit Alpha [NCIt concept]
- Low Affinity Immunoglobulin Epsilon Fc Receptor [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 6 [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- FCER2 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- IL2RG wt Allele [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL4R wt Allele [NCIt concept]
- IRS1 wt Allele [NCIt concept]
- JAK1 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- STAT6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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