Signal Transducer and Activator of Transcription 6

Preferred Label : Signal Transducer and Activator of Transcription 6;

NCIt synonyms : Transcription Factor IL-4 STAT; STAT6; IL-4 Stat; Signal Transducer and Activator of Transcription-6;

NCIt definition : Signal transducer and activator of transcription 6 (847 aa, 94 kDa) is encoded by the human STAT6 gene. This protein is involved in the modulation of both gene expression and signal transduction.;

NCIt note : This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this protein in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. (LocusLink);

Details

Origin ID

C28670;

UMLS CUI

C0297890;

OMIM relation
- Signal transducer and activator of transcription 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- STAT6 protein, human [MeSH concept]
- STAT6 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- STAT6 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Signal Transducer and Activator of Transcription [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
gene_product_is_element_in_pathway
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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