RAC-Alpha Serine/Threonine Kinase

Preferred Label : RAC-Alpha Serine/Threonine Kinase;

NCIt synonyms : PKB; PKB Protein; Protein Kinase B Alpha; RAC-Alpha Protein Kinase; PRKBA; RAC-PK-Alpha; AKT1; RAC; C-AKT; Proto-Oncogene c-Akt; Protein Kinase B; EC 2.7.11.1; RAC-Alpha Serine-Threonine Kinase; PKB Alpha; Protein Kinase B-Alpha;

NCIt definition : RAC-alpha serine/threonine-protein kinase (480 aa, 56 kDa) is encoded by the human AKT1 gene. This protein is involved in signal transduction, serine/threonine phosphorylation, apoptosis regulation and neurogenesis.;

Details

Origin ID

C17579;

UMLS CUI

C0668624;

Currated CISMeF NLP mapping
- rac [IUPAC Term]
OMIM relation
- Akt serine/threonine kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- AKT1 protein, human [MeSH concept]
- AKT1 protein, human [MeSH Supplementary Concept]
- Proto-Oncogene proteins c-akt1 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AKT1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- 7-Hydroxystaurosporine [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_gene_product_variant
- AKT1 NP_001014431.1:p.E17K [NCIt concept]
- AKT1 Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- AKT Signaling Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Adherens Junction Formation Pathway [NCIt concept]
- Adipocytokine Signaling Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Angiogenesis Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Aurora A Signaling Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- B-Cell Survival Pathway [NCIt concept]
- BAD Regulation Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
- Beta-Catenin Accumulation Pathway [NCIt concept]
- CD40/CD40L Signaling Pathway [NCIt concept]
- CREB Activation Signaling Pathway [NCIt concept]
- CXCR3-Mediated Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Class I PI3K Signaling Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- Corticosteroid Cardioprotection Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Endothelin Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Hedgehog Family-Mediated Signaling Pathway [NCIt concept]
- Hedgehog Signaling Events Mediated by Gli Family Proteins [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- IFN Gamma Signaling Pathway [NCIt concept]
- IGF1 Pathway [NCIt concept]
- IGF1R Antiapoptosis Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Insulin-Mediated Glucose Transport Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Ion Channels in Vascular Endothelium Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Longevity Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- Nephrin Signaling Pathway in the Kidney Podocyte [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Neuronal Survival Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Nitric Oxide Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Nongenotropic Androgen Signaling Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Phosphoinositide Pathway [NCIt concept]
- Phospholipase C Signaling Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Ras Signaling Pathway [NCIt concept]
- Reelin Signaling Pathway PID [NCIt concept]
- Regulation of Apoptosis Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Retinoic Acid Receptor Family-Mediated Signaling Pathway [NCIt concept]
- Ribosomal Biogenesis Pathway [NCIt concept]
- Skeletal Muscle Hypertrophy Pathway [NCIt concept]
- Skeletal Myogenesis Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 3 Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Telomere Pathway [NCIt concept]
- Thromboxane A2 Receptor Family Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Trka Receptor Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- VEGFR1 Signaling Pathway [NCIt concept]
- VEGFR1 and VEGFR2 Signaling [NCIt concept]
- VEGFR3 Lymphatic Signaling Pathway [NCIt concept]
- eIF4 Regulation Pathway [NCIt concept]
- mTOR Signaling Pathway BioCarta [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
- mTOR Signaling Pathway PID [NCIt concept]
- p53 Pathway for Transcriptional Regulation [NCIt concept]
gene_product_is_physical_part_of
- Protein Kinase B [NCIt concept]
gene_product_plays_role_in_biological_process
- Negative Regulation of Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- 7-Hydroxystaurosporine [NCIt concept]
- Akt-1 Antisense Oligonucleotide WGI-0301 [NCIt concept]
- Triciribine Phosphate [NCIt concept]

Keyword's position in hierarchy(ies) :

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