Interleukin-4 Receptor Subunit Alpha

Preferred Label : Interleukin-4 Receptor Subunit Alpha;

NCIt synonyms : IL4R; CD124; IL4RA; Interleukin 4 Receptor Alpha; Interleukin-4 Receptor; Interleukin-4 Receptor Alpha; IL-4R-Alpha; Interleukin 4 Receptor; IL-4R Subunit Alpha; IL-4RA; IL-4 Receptor Subunit Alpha; Interleukin-4 Receptor Alpha Chain;

NCIt definition : Interleukin-4 receptor subunit alpha (825 aa, 90 kDa) is encoded by the human IL4R gene. This protein plays a role in both interleukin-4 signaling and immunoglobulin E production.;

NCIt note : Interleukin-4 receptor subunit alpha serves as the high-affinity interleukin 4 (IL4) receptor when complexed with the cytokine receptor common subunit beta.; Interleukin-4 receptor subunit alpha can be cleaved to produce soluble interleukin-4 receptor subunit alpha (IL-4-binding protein). (UniProt);

Details

Origin ID

C26268;

UMLS CUI

C1620077;

Currated CISMeF NLP mapping
- receptors, Interleukin-4 [MeSH concept]
- receptors, interleukin-4 [MeSH Descriptor]
OMIM relation
- Interleukin 4 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL4R protein, human [MeSH concept]
- IL4R protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL4R Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Binetrakin [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
- Th1/Th2 Differentiation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Dupilumab [NCIt concept]
- Stapokibart [NCIt concept]

Keyword's position in hierarchy(ies) :

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