Preferred Label : Stapokibart;
NCIt synonyms : Anti-IL-4RA Monoclonal Antibody CM310; Anti-IL-4 Receptor Alpha Monoclonal Antibody CM310; Anti-interleukin-4 Receptor Subunit Alpha Monoclonal Antibody CM310;
NCIt definition : A recombinant humanized monoclonal antibody directed against the alpha chain of the
interleukin-4 receptor (IL-4RA; IL-4R alpha), with potential anti-inflammatory and
immunomodulatory activities. Upon administration, stapokibart selectively binds to
IL-4RA. This disrupts IL-4/IL-13 signaling and prevents the activation of downstream
pathways that mediate type 2 inflammation. IL-4 and IL-13 receptors are present on
the surface of numerous cells involved in the pathophysiology of type-2 helper T-cell
(Th2) allergic responses, including B-lymphocytes, eosinophils, dendritic cells (DCs),
monocytes, macrophages, basophils, keratinocytes, bronchial epithelial cells, endothelial
cells, fibroblasts, and airway smooth muscle cells.;
UNII : L2REN9TU2D;
CAS number : 2734715-10-5;
Molecule name : CM 310; CM-310;
NCI Metathesaurus CUI : CL1794074;
Origin ID : C188799;
UMLS CUI : C5854887;
Currated CISMeF NLP mapping
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
