Growth Factor Receptor-Bound Protein 2

Preferred Label : Growth Factor Receptor-Bound Protein 2;

NCIt synonyms : ASH Protein; Growth Factor Receptor Bound Protein 2; GRB-2; GRB2 Protein; GRB2; Ash-L; Adapter Protein GRB2; Protein Ash; SH2/SH3 Adapter GRB2; Growth Factor Receptor-Bound Protein-2; Abundant SRC Homology Protein;

NCIt definition : Growth factor receptor-bound protein 2 (217 aa, 25 kDa) is encoded by the human GRB2 gene. This protein is involved in the progression of epidermal growth factor-mediated signaling pathways.;

NCIt note : Growth factor receptor-bound protein 2 (GRB2) isoform 2 (GRB3-3) lacks the SH2 domain and acts in a dominant negative manner to inhibit epidermal growth factor signaling. (UniProt);

Details

Origin ID

C26222;

UMLS CUI

C1436247;

OMIM relation
- Growth factor receptor-bound protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GRB2 protein, human [MeSH Supplementary Concept]
- GRB2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- GRB2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- CREB Activation Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Dorso-Ventral Axis Formation Pathway [NCIt concept]
- EGF Receptor Downregulation by CBL Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- HBx Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IGF1R Antiapoptosis Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL3 Signaling Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Nerve Growth Factor Pathway [NCIt concept]
- Neuronal Survival Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- SRC Tyrosine Kinase Activation Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Activation Co-Stimulatory Signaling Pathway [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
- Trka Receptor Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_product_is_physical_part_of
- EGFR-GRB2 Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
is_target
- Prexigebersen [NCIt concept]

Keyword's position in hierarchy(ies) :

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