PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway

Preferred Label : PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway;

NCIt related terms : PTEN dependent cell cycle arrest and apoptosis;

Alternative definition : BIOCARTA: PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of phosphatidylinositol 3-kinase. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain; it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated in a complex manner via phosphorylation of AKT on Thr308 and Ser473 by PDK1 and ILK (integrin-linked kinase) respectively. Inactivation of PTEN will constitutively activate PKB/AKT pathway. In addition to its role in regulating the PI 3-K/AKT cell survival pathway, PTEN also inhibits growth factor-induced Shc phosphorylation and suppresses the mitogen-activated protein (MAP) kinase signaling pathway. PTEN also interacts with FAK, a key molecule implicated in integrin signaling pathways, and it directly dephosphorylates tyrosine-phosphorylated FAK. PTEN down-regulation of p130CAS through FAK results in inhibition of cell migration and spreading. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ptenPathway;

Details

Origin ID

C39205;

UMLS CUI

C1518829;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1B [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Forkhead Box Protein O3 [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Integrin-Linked Protein Kinase [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Retinoblastoma-Like Protein 2 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- BCAR1 wt Allele [NCIt concept]
- CDKN1B wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- FOXO3 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- ILK wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PTEN wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- RBL2 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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