Focal Adhesion Kinase 1

Preferred Label : Focal Adhesion Kinase 1;

NCIt synonyms : PTK2; PTK2 Protein Tyrosine Kinase 2; Focal Adhesion Kinase; FAK1; FAK; p125FAK; Protein Phosphatase 1 Regulatory Subunit 71; pp125FAK; FADK 1; PPP1R71; FRNK; Focal Adhesion Kinase-Related Nonkinase; EC 2.7.10.2; Focal Adhesion Kinase-1;

NCIt definition : Focal adhesion kinase 1 (1052 aa, 119 kDa) is encoded by the human PTK2 gene. This protein is involved in signaling, tyrosine phosphorylation, cell migration, angiogenesis and embryonic development.;

Details

Origin ID

C17572;

UMLS CUI

C1565427;

Currated CISMeF NLP mapping
- focal adhesion kinase 1 [MeSH Descriptor]
- focal adhesion kinase 1 [MeSH concept]
OMIM relation
- Protein-tyrosine kinase, cytoplasmic [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTK2 protein, human [MeSH concept]
- PTK2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- PTK2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Agrin Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Angiogenesis Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- CCR3 Signaling Pathway [NCIt concept]
- CXCR4 Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- Calpain-1 Cell Spread Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Cell to Cell Adhesion Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Ephrin A2 Forward Signaling Pathway [NCIt concept]
- Ephrin B Forward Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- IGF1 Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Nectin Adhesion Pathway [NCIt concept]
- Nongenotropic Androgen Signaling Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway [NCIt concept]
- Regulation of Apoptosis Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- VEGFR1 and VEGFR2 Signaling [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- ALK-FAK Inhibitor CEP-37440 [NCIt concept]
- FAK Inhibitor VS-4718 [NCIt concept]
- Ifebemtinib [NCIt concept]
- Masitinib Mesylate [NCIt concept]
- Repotrectinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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