" /> CDKN1B wt Allele - CISMeF





Preferred Label : CDKN1B wt Allele;

NCIt synonyms : Cyclin Dependent Kinase Inhibitor 1B wt Allele; Kip1; P27KIP1; CDKN4; MEN1B; MEN4; Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) Gene;

NCIt definition : Human CDKN1B wild-type allele is located within 12p13.1-p12 and is approximately 5 kb in length. This allele, which encodes cyclin-dependent kinase inhibitor 1B protein, plays a role in the progression of the cell cycle at the G1 phase.;

NCIt note : CDKN1B expression is regulated by PI3K/PKB and RAS/RAL regulated AFX-like forkhead proteins. PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to CDKN1B, increasing CDKN1B, decreasing cyclin D1, and inhibiting AKT phosphorylation. Involved in G1 arrest, nuclear CDKN1B inhibits cyclin/CDK complexes. Low CDKN1B expression is associated with a poor clinical prognosis.;

GenBank Accession Number : NM_004064;

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14/05/2024


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