Preferred Label : CDK Regulation Pathway;
NCIt related terms : CDK Regulation of DNA Replication;
Alternative definition : BIOCARTA: Initiation of DNA replication in eukaryotes is a highly conserved, multi-step
process (replication licensing) designed to restrict initiation events to once per
replication origin per S phase. Its control has been uncovered by the discovery of
the cyclin dependent kinases (CDKs) as master regulators of the cell cycle and the
initiator proteins of DNA replication, such as the Origin Recognition Complex (ORC),
Cdc6/18, Cdt1 and the mini-chromosome maintenance complex (Mcm). The proteins and
the sequence of events involved in this process are conserved throughout the eukaryotic
kingdom. First, the ORC comprised of six proteins binds to replication origins in
the chromosomal DNA. At the end of mitosis, ORC, Cdc6/18 and Cdt1 assist the binding
of Mcm proteins 2-7 to chromatin, and chromatin becomes licensed for replication.
The activated Mcm complex functions as a replicating helicase and moves along with
the replication fork to bring the origins to the unlicensed state. The cycling of
CDK activity in the cell cycle regulates the two states of replication origins, the
licensed state in G1-phase and the unlicensed state for the rest of the cell cycle.
The restriction on licensing is relieved when CDK falls off at the completion of mitosis
to allow a new round of replication. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_mcmPathway;
Origin ID : C39148;
UMLS CUI : C1511433;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
