DNA Replication Licensing Factor MCM5

Preferred Label : DNA Replication Licensing Factor MCM5;

NCIt synonyms : CDC46; CDC46 Homolog; P1-CDC46; MCM5; EC 3.6.4.12; DNA Replication Licensing Factor-MCM5;

NCIt definition : DNA replication licensing factor MCM5 (734 aa, 82 kDa) is encoded by the human MCM5 gene. This protein plays a role in DNA replication.;

NCIt note : A stable dimeric complex of MCM5/MCM3 associates with replication-specific DNA polymerase alpha-primase complex. MCM3 is acetylated by MCM3AP. MCM proteins also associate with RNA Pol II holoenzyme as components of the transcriptional apparatus. MCM5 interacts directly with the TAD of STAT1, enhancing transcription activation.;

Details

Origin ID

C33910;

UMLS CUI

C0296863;

Automatic exact mappings (from CISMeF team)
- Minichromosome maintenance complex component 5 [OMIM gene]
- minichromosome maintenance complex component 5 [MeSH Descriptor]
OMIM relation
- Minichromosome maintenance complex component 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCM5 protein, human [MeSH Supplementary Concept]
- MCM5 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Licensing Factor Gene [NCIt concept]
- MCM5 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- DNA Binding Protein [NCIt concept]
- MCM Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- CDK Regulation Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
- Replication Initiation [NCIt concept]
- Replication Licensing [NCIt concept]
- Transcription [NCIt concept]

Keyword's position in hierarchy(ies) :

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