Replication Licensing

Preferred Label : Replication Licensing;

NCIt definition : A process that limits duplication of the genome to once per cell division cycle. In eukaryotes replication origins are limited to a single initiation event during G1 by temporally separating the assembly of the pre-replication complex (pre-RC) from the initiation of DNA synthesis. An elaborate mechanism regulates the ordered loading of proteins at replication origins which convert a poised, but inactive, minichromosome maintenance (MCM) complex into an enzymatically active helicase.;

Details

Origin ID

C20365;

UMLS CUI

C1514852;

Semantic type(s)
- Genetic Function [UMLS semantic type]
biological_process_has_result_biological_process
- DNA Replication [NCIt concept]
biological_process_involves_gene_product
- Cell Division Control Protein 6 Homolog [NCIt concept]
- DNA Replication Factor Cdt1 [NCIt concept]
- DNA Replication Licensing Factor MCM2 [NCIt concept]
- DNA Replication Licensing Factor MCM3 [NCIt concept]
- DNA Replication Licensing Factor MCM4 [NCIt concept]
- DNA Replication Licensing Factor MCM5 [NCIt concept]
- DNA Replication Licensing Factor MCM6 [NCIt concept]
- DNA Replication Licensing Factor MCM7 [NCIt concept]
- Licensing Factor [NCIt concept]
process_involves_gene
- CDT1 Gene [NCIt concept]
- CDT1 wt Allele [NCIt concept]
- MCM2 Gene [NCIt concept]
- MCM2 wt Allele [NCIt concept]
- MCM4 Gene [NCIt concept]
- MCM4 wt Allele [NCIt concept]
- MCM5 Gene [NCIt concept]
- MCM5 wt Allele [NCIt concept]
- MCM6 Gene [NCIt concept]
- MCM6 wt Allele [NCIt concept]
- MCM7 Gene [NCIt concept]
- MCM7 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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