DNA Replication Licensing Factor MCM7

Preferred Label : DNA Replication Licensing Factor MCM7;

NCIt synonyms : CDC47 Homolog; P1CDC47; P1.1-MCM3; p85MCM; CDC47; PNAS-146; Minichromosome Maintenance Protein 7; EC 3.6.4.12; DNA Replication Licensing Factor-MCM7;

NCIt definition : DNA replication licensing factor MCM7 (8719 aa, 81 kDa) is encoded by the human MCM7 gene. This protein plays a role in the synthesis of a single copy of a genome before mitosis.;

NCIt note : A stable MCM2/4/6/7 complex possesses DNA helicase activity and may act as a DNA unwinding enzyme. CDC45 binds to MCM7 and DNA polymerase alpha p70 subunit in the final sequential step of active initiation complex assembly and recruits DNA polymerase alpha to origins of replication. Nonenzymatic p70 forms a tight complex with the catalytic DNA polymerase alpha p180 subunit. The hexameric MCM2-7 complex is a key component of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. CDK4 associates with MCM7 and MCM7 binds RB1/RB.;

Details

Origin ID

C33912;

UMLS CUI

C0754407;

Automatic exact mappings (from CISMeF team)
- Minichromosome maintenance complex component 7 [OMIM gene]
- minichromosome maintenance complex component 7 [MeSH Descriptor]
OMIM relation
- Minichromosome maintenance complex component 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCM7 protein, human [MeSH concept]
- MCM7 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Licensing Factor Gene [NCIt concept]
- MCM7 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- MCM Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
- Replication Initiation [NCIt concept]
- Replication Licensing [NCIt concept]

Keyword's position in hierarchy(ies) :

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