" /> MCM Protein - CISMeF





Preferred Label : MCM Protein;

NCIt synonyms : Minichromosome Maintenance Protein;

NCIt definition : The MCM proteins are essential replication initiation factors. The best known among them are a family of six structurally related proteins, MCM2-7, which are evolutionally conserved in all eukaryotes. The MCM2-7 proteins form a hexameric complex. This complex is a key component of the prereplication complex that assembles at replication origins during early G1 phase. The MCM2-7 proteins may be involved not only in the initiation but also in the elongation of DNA replication. Orchestration of the functional interactions between the MCM2-7 proteins and other components of the prereplication complex by cell cycle-dependent protein kinases results in initiation of DNA synthesis once every cell cycle. (from PMID 10872463 and NCI);

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
14/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.